Vascular reactivity studies Mesenteric artery rings were suspended in organ baths for the determination of changes in isometric tension, as described previously [ 21 ]. Anal Biochem Explore the pathogenesis and for drug research. We suggest that a high-fat diet combined with alcohol intake contributed to delayed skin wound healing through increase of the inflammatory phase and promoting oxidative stress, which may have led to morphological alterations and impaired matrix remodeling.
Blood Marker Tests Blood was collected during euthanasia, after 12 h of fasting, through cardiac puncture using a heparinized syringe. J Clin Invest Using a 40x objective lens, 10 histological fields were analyzed with a total area of 1. Krishnaswamy, M.
Sirius Red staining. Such models allow researchers to control, in vivo, genetic, and environmental factors that may influence the development of the disease and its secondary complications, therefore gaining useful information on its management and treatment in humans.
FEBS Lett On days 14 and 21, there was no difference among experimental groups. Teixeira, L. This increase in tissue oxidative stress may also be associated with diabetes or other changes in insulin levels [ 58 ]. Effects of alcohol and high-fat diet on the total amount of type I collagen atype III collagen band elastic fibers c in skin wounds of Wistar rats.
Cupertino et al. Diabetologia Diabetes is known to produce substantial changes in intracellular metabolism in most tissues, including liver [ 13 ].
Photomicrographs showing blood vessel distribution on scar tissue in Wistar rats. Figure 1 shows the experimental design used to evaluate the time-dependent effects of alcohol and high-fat diet intake on wound healing in rats.
These findings corroborate the increased number of mast cells in rats consuming both alcohol and a high-fat diet. However, a direct comparison between Wistar and Sprague-Dawley SD Rat as models of high-fat HF diet-induced obesity has not been adequately evaluated so far. Cheng, W. Acetaldehyde oxidation and pH alterations to the epidermis stratum corneum were also reported as factors extending the inflammation process in scar tissue when ethanol consumption is involved [ 2 ].
According to Nascimento and Monte-Alto-Costa [ 36 ], obese mice had higher lipid peroxidation compared to normal weight mice, which indicates cell membrane disorganization in the overweight group.
Our results showed that rats receiving high-fat diet and alcohol had a lower vascularization and therefore a delay in wound closure.
We compared the impact of a diet rich in both sugar and fat with that of a sugar-rich diet without the addition of fat. Each sample was experimentally analyzed in triplicate.
Duration of diet regimen in weeks W before STZ treatment.Nutrition Research and Practice (), 2(4), ⓒ The Korean Nutrition Society and the Korean Society of Community Nutrition Effect of Chlorella vulgaris on lipid metabolism in Wistar rats fed high fat diet.
Introduction. Wistar and Sprague Dawley (SD) rats are generally used as models for the cholesterol metabolism experiments. They are acceptable to high fat diet-induced disorders with individual variations, including dyslipidemia and abnormal cardiac vsfmorocco.com: Arunwan Udomkasemsab, Pattaneeya Prangthip.
RESEARCH PAPER High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat Claudia Marques a, b, Manuela Meireles a,Sonia Norberto, Joana Leite, Joana Freitas,c, Diogo Pestana.
sides on metabolic, hormonal, and structural disorders of the adrenal medulla in Wistar rats fed a high-fat diet. Material and methods. Twenty six Wistar rats were distributed as follows: six control animals received a standard.
In the past decades, obesity and associated metabolic complications have reached epidemic proportions. For the study of these pathologies, a number of animal models have been developed.
However, a direct comparison between Wistar and Sprague-Dawley (SD) Rat as models of high-fat (HF) diet-inducedCited by: The aim of this study was to assess the effect of an addition of sweet cherry fruit or leaves (unexplored until now) to high fat-cholesterol (HFC) diet on selected biochemical parameters and expression of genes involved in fatty acid metabolism in male Wistar vsfmorocco.com: Kinga Dziadek, Aneta Kopeć, Ewa Piątkowska.